A research team working on new drug screening platforms, a major special S&T project initiated by the Ministry of Science and Technology, has successfully applied fluorescent polarization technology in screening new drugs. The team has developed two high flux drug screening models for cardiovascular diseases, the first of its kind in the nation.

The project has produced two fluorescent marker targets for fluorescent polarization applications, and rolled out two high flux drug screening models through matching process. The new models are sensitive enough to screen out small molecule compounds matched with new targets. The active specimens or compounds screened out by models are not only used for new drug development, but are also valuable for studying new targets. With numerous merits, including easy operation, high sensitivity, and low fake positive or negative rate, all reagents can be prepared in a lab environment, which reduces screening costs. Up to date, the two models have screened out some 160,000 specimens, and sorted out 10 active specimens of research or development perspectives.