Not long ago, Prof. TANG Yun at Fudan University unveiled an IN structure model using computational biology, from which scientists can design HIV-I inhibiting medicines. With HIV-1 integrase as its full name, IN is responsible for HIV-1 integration in human body. It has long been an important topic to reveal its complete structure before working to inhibit it.
Researchers, using molecular simulations in computational biology, developed a structure model showing the compounds made up of full-length IN protein and its viruses and human DNA. The model unveils the interactions between IN and AIDS viruses and human DNA. TANG said that scientists could expect to produce new anti-AIDS drugs based on the structure model. Future new drugs derived from the model will be named as HIV integrase inhibitors, as IN is the integrase of HIV viruses. |
